Kinase is a class of enzyme that helps to transfer phosphate groups to the targeted substrate from molecules with high energy such as adenosine triphosphate (ADP). Disrupted or inappropriate kinase activity has been associated with several chronic diseases such as diabetes, neurological disorders, cancer, and cardiovascular disorders.
The rising prevalence of chronic diseases such as cancer and diabetes is one of the primary factors driving the global kinase-targeted therapeutics market. The World Diabetes Foundation (WDF) estimates the number of people suffering from diabetes to reach 438 million by 2030. Similarly, the World Cancer Research Fund International projects the count of people suffering from cancer across the world to reach 21 million by the same year. Kinases vary on the basis of molecules on which they act. Some of them are lipid kinase, protein kinase, and carbohydrate kinase.
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Kinase is an enzyme class that helps to transfer phosphate groups to certain substrate from high energy molecules such as adenosine triphosphate (ADP). This phenomenon of phosphate group transfer is termed as phosphorylation. Kinases control various cellular activities such as cell signaling, cellular transport, protein regulation, secretory processes and cellular metabolism. Based on the molecule on which kinases act, they can be categorized as: protein kinase, lipid kinase, carbohydrate kinase and other kinase (thymidine kinase and riboflavin kinase). Protein kinases include mitogen activated protein kinases and cyclin dependent kinases. Lipid kinases include sphingosine kinases and phosphatidylinositol kinases.
Protein kinase acts on tyrosine, serine, histidine or threonine content of protein and modify the protein functionality by either increasing or decreasing their activities. Lipid kinase acts on the cell or plasma membrane along with organelles membrane. Activity of kinase on membrane helps alter reactivity of lipids and hence result in signal transmission. Carbohydrate kinases (hexokinase and phosphofructokinase) act on bisphosphoglycerate and other carbohydrate molecule to release energy. Among all the aforementioned kinases, protein kinases therapeutics accounts for the largest share of the total market owing to their wider application area coupled with their large utilization in developing and manufacturing therapeutic drugs.
Many diseases are caused due to inappropriate activities of kinases. Aberrant kinase activities also results in proliferative or inflammatory responses for the diseases such as cancer and rheumatoid arthritis. Kinase activities have also resulted in cardiovascular diseases, diabetes and neurological disorders. Hence, any disruption in the activities of any of the kinase may result in adverse effects on the people. Kinase-targeted therapeutics include all those drugs that act on the kinases that are affecting negatively to the people. These drugs enable the physicians to treat the disease from the root cause and help eliminating the adverse effects of the disease.
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Owing to rising incidences of diabetes the population, the market for kinase-targeted therapeutics is poised to grow at a significant CAGR from the period 2013 to 2019. The World Diabetes Foundation (WDF) has estimated that nearly 285 million populace lived with diabetes in the year 2010 that accounted for 6.4% of the world’s youth population in the same year. This number is poised to grow to 438 million by 2030, corresponding to 7.8% of the world’s adult population. The National Diabetic Fact Sheet of the U.S., which was released in January 2011, states that 25.8 million children and adults suffer from diabetes which accounts for 8.3% of the total U.S. population.
Almost 1.9 million new cases were diagnosed in people aged 20 years and above in the U.S. alone. Similarly, increasing number of cancer patients across the globe also augments the growth of kinase-targeted therapeutics market. It has been estimated by the World Cancer Research Fund International that by 2030 around 21 million people will suffer from cancer worldwide.
In 2012, North America accounted for the largest share of global kinase-targeted therapeutics market owing to presence of large geriatric population. Elder people are prone to various diseases such as cardiovascular diseases and other that can be easily treated by the uptake of kinase-targeted therapeutic drugs.
Similarly, domicile of big manufacturers of kinase-targeted therapeutic drugs in the region has further supported the large market size of kinase-targeted therapeutics market. The major players operating in kinase-targeted therapeutics market include Abbott Laboratories, Eli Lilly and Company, Array BioPharma, Inc., Avila Therapeutics, Inc. and Bristol-Myers Squibb Co amongst other significant players.
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