Frontier Pharma: Parkinson's Disease - Identifying and Commercializing First-in-Class Innovation

Parkinson's Disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease, affecting around 7.4 million people worldwide. It is caused by the progressive loss of dopamine-producing neurons in the substantia nigra within the basal ganglia. The main motor symptoms are tremors, bradykinesia and rigidity, although symptoms vary between individuals. As the disease progresses to more advanced stages, increasing symptoms and complications develop, which can cause severe disability in patients.

The current market offers a number of anti-PD treatment options which provide symptomatic relief. Levodopa is currently the gold standard therapy, with other drug classes including dopamine agonists and Monoamine Oxidase B (MAO-B) inhibitors also used to treat early and advanced cases. With no current treatment showing effectiveness in delaying the course of the disease, PD remains incurable. The high unmet need for a disease-modifying therapy is reflected in the pipeline, where a high proportion of early-stage first-in-class programs target the potential pathogenic mechanisms underlying neurodegeneration.

Full Report Details at
- http://www.fastmr.com/prod/1123032_frontier_pharma_parkinsons.aspx?afid=301

Report Scope

PD is a crowded market with many neuromodulatory drug classes available. However, a disease-modifying therapy with neuroprotective effects is yet to be developed.
- What are the primary mechanisms that are thought to contribute to neuronal death?
- What are the major barriers facing the development of investigational neuroprotective candidates?
Analysis reveals a high level of innovation and diversity in the pipeline, with 121 first-in-class programs acting on 57 unique molecular targets.
Neuromodulatory targets remain the dominant target family, particularly in the late-stage pipeline.
- What are the first-in-class families with a significant presence?
- How well do they align with the underlying pathways governing neuronal death in PD?
Some of the first-in-class targets have a potentially stronger chance of being translated into novel treatments for PD.
- What is the scientific rationale behind these targets? How do they perform in Preclinical studies?
- What are the commonly used disease models and the parameters measuring neuroprotective effects in PD animal studies?
Deals involving first-in-class PD products are more likely to be made in earlier stages of development than non-first-in-class deals.
- What is the dominant molecular target in the PD deals landscape?
- What are the promising first-in-class products still available for future licensing?

Reasons to Get this Report

This report will allow you to -

* Understand the current clinical and commercial landscape by considering the proposed pathogenic processes underlying PD neurodegeneration, diagnosis, prognosis, and the available treatment options and their usage in early and advanced PD.

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