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Proliferative vitreoretinopathy (PVR) remains the most commonly observed failure in the surgery of rhegmatogenous retinal detachment (RRD), albeit substantial efforts have been taken to better understand and manage the condition in the past. Basic research indicates that proliferative vitreoretinopathy illustrates scarring - end-stage of wound healing process, which occurs post-retinal detachment surgery. Current medical treatment for PVR has been directed toward the prevention of inflammation first stage of wound-healing process, and inhibition of cell proliferation second stage.
Surgery for proliferative vitreoretinopathy, at present, demonstrates high anatomical success rate, despite disappointing visual results. Utilization of adjunctive treatments for preventing cellular proliferation has been deemed effective in the treatment & prevention of PVR, or post-surgery recurrences. Proliferation control and strategies directed toward the improvement of visual outcome are imperative focus areas for future studies in PVR. In addition, researches on the peri-retinal and intra-retinal pathology of proliferative vitreoretinopathy have illustrated characteristic alterations, which will significantly influence surgical management and visual outcome.
Proliferative Vitreoretinopathy Market: Potential of Systemic Anti-TNFα Treatment in Reduction of PVR to Influence Future Developments
Lack of effective prophylaxis or treatment has made proliferative vitreoretinopathy one of the most devastating complications witnessed in RRD. TNFα has been implied in PVR development, which in turn necessitates blockade of this factor for reducing or preventing onset of proliferative vitreoretinopathy. However, systemic treatment of PVR using anti-TNFα entails several side-effects and risks, and employment of such drugs for PVR treatment is not yet justified. Researchers have sought indirect approaches for determination of effectiveness of anti-TNFα in protection against PVR development post-RRD surgery.
Despite sound principles on which the approaches are based, low prevalence of patients affected with RRD, chronic inflammatory diseases, and PVR has prevented researchers from drawing conclusions with regard to potential effectiveness of the anti-TNFα therapy as prophylactic treatment for preventing or reducing PVR incidences following RRD. However, these approaches hold promise in promoting future in-vivo studies, and randomizing clinical trials in humans with the help of more preclinical research.
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Proliferative Vitreoretinopathy Market: Hospital Pharmacies Continue to Account for Bulk Market Shares
Hospital pharmacies are leading consumers in the pharmacy industry. Policymakers are becoming more aware about importance of offering effective pharmacy services coupled with safe and rational use of medications. In case of proliferative vitreoretinopathy, hospital pharmacies are considered to be radical asset of the modern pharmacy sector. They are vital part of hospitals and clinics, ensuring safe, effective, and economic use of drugs. According to the study, hospital pharmacies will continue to account for bulk shares of the market in the period of forecast.
Injectables will remain preferred over other mode of administrations of proliferative vitreoretinopathy management drugs. Treatment of PVR through intravitreal injectables has been considered beneficial as they delivery drugs directly to retina and vitreous. Simplicity of achieving intravitreal injection by doctors is a key factor driving adoption of this method. Subretinal injection has been gaining ground in the treatment of PVR, as it directly affects the resident cells & tissues in subretinal space. However, requirement for highly proficient and stable operators for subretinal injection continues to prevail as a major concern in the healthcare sector.
Table of Content:
- Executive Summary
1.1. Summarizing Key Findings
1.2. Trends and Developments
1.3. Strategic Themes
1.4. Highlighting Action Area Wheel of Fortune
- Global Proliferative Vitreoretinopathy Market Overview
2.2. Market Definition
2.3. Market Taxonomy and Segments Captured
- Global Proliferative Vitreoretinopathy Market Outlook
3.1. Market Size (US$ Mn) and Forecast, 2013-2027
3.2. Market Y-o-Y Growth
3.3. Forecast Factors and Relevance Impact
- Global Proliferative Vitreoretinopathy Market Dynamics
- Supply Chain Assessment
- Actionable Insights and Analysis
North America will continue to be at the forefront of the proliferative vitreoretinopathy market, with approximately two-fifth market revenue share estimated for the region by 2027-end. Favorable government policies and reimbursements provided by the government, along with the occupancy of robust healthcare facilities are key growth determinants for growth of the proliferative vitreoretinopathy market in North America. Additionally, strong penetration of PVR management drugs such as "lornoxicam" has further supported demand for treatment of PVR in the region.
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