Alport Syndrome is the hereditary genetic disorder characterized by glomerulonephritis, abnormal vision, acute hearing loss and end-stage renal disease. Alport Syndrome is also called the hereditary nephritis. Alport syndrome is the rare disease usually affecting the male population. According to the National Institute of Health (NIH), alport syndrome occurs in approximately 1 in 50,000 newborns. People affected from alport syndrome experience progressive loss of kidney function. Alport syndrome includes symptoms such as hematuria (blood in urine), high blood pressure, proteinuria (protein in the urine), edema (swelling in the legs, ankle, feet and around the eyes. Alport syndrome is basically caused by the mutation in COL4A3, COL4A4, and COL4A5. Mutation in these genes outcomes in abnormalities of the type IV collagen in glomeruli which restricts kidneys function to filter blood properly. About 80% of alport syndrome cases are caused by COL4A5 gene mutation and inherited in X linked pattern. Approximately, 15%-20% alport syndrome results from COL4A3 and COL4A4 gene mutation. There is no definite medication existing for alport syndrome treatment. ACE inhibitors, angiotensin receptor blockers (ARB’s) and diuretic drugs are used for alport syndrome treatment. Angiotensin converting enzyme (ACE) inhibitor is the blood pressure medication given for alport syndrome treatment when the elevated level of protein is detected in the urine. ACE inhibitors inhibit the enzyme in the body from producing angiotensin II. ACE inhibitors such as benazepril, cilazapril, enalapril, fosinopril, quinapril, perinopril are used to treat alport syndrome treatment.
Alport Syndrome Treatment Market: Drivers and Restraints
The growing prevalence of the genetic disorder is expected to be the major factor driving the growth of the Alport syndrome treatment market over the forecast period. Increasing high blood pressure problems are secondary factors expected to boost the demand for alport syndrome treatment drugs. Increasing the diagnosis rate due to screening programs, favorable medicare policies, increasing healthcare expenditures are another reason for the growth of the alport syndrome treatment market. Increasing research and development for the treatment of rare diseases is expected to boost the growth of alport syndrome treatment market. The side effect associated with some alport syndrome treatment medication and less awareness regarding diseases among the general population are some of the factors expected to restrain the growth of the alport syndrome treatment market.
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