The latest research, conducted by Dr Joerg T Albert, a Deafness Research UK research fellow at the UCL Ear Institute, together with scientists at the University of Cologne, shows that fruit flies have ears which mechanically amplify sound signals in a remarkably similar way to the sensory cells found in the inner ear of vertebrates including humans. The finding means that the wealth of genetic techniques already available to study the fruit fly can now be used to target how the ear works.
Dr Albert says, "The biophysical parallels between the ways both fruit flies and humans convert sound into nerve signals are truly amazing. We may be allowed to hope that these mechanistic similarities extend further down to the genes and molecules that bring about hearing. But even if it finally should turn out that hearing in fruit flies relies on different molecules than does hearing in humans, the little fruit fly can help us find answers to some key questions of hearing research and – what is sometimes even more important – will surely help us ask the right questions."
The work is welcomed by Deafness Research UK, the country’s only medical research charity for deaf people. Vivienne Michael, Chief Executive of Deafness Research UK, says: "This is an important advance that paves the way toward a clear understanding of the genetics of deafness.
The charity will continue to support cutting-edge research through its Fellowship programme at the UCL Ear Institute and at other top research centres in the UK to achieve our goal of securing radical improvements in the prevention, diagnosis and treatment of all forms of hearing impairment".
There are nine million deaf and hard of hearing people in the UK and in most cases deafness results from loss of sensory cells in the inner ear known as "hair" cells. The cells can be damaged and lost through ageing, noise, genetic defects and certain drugs and, because the cells don’t regenerate, the result is progressive - and irreversible - hearing loss. Damage to these cells can also lead to tinnitus which affects around 5 million people in the UK.
Björn Nadrowski, Jörg T. Albert and Martin C. Göpfert report a mathematical model of the process, known as transduction, used by Drosophila melanogaster (the fruit fly) to transform mechanical energy from sound waves into electrical signals. In vertebrates this transduction is performed by hair cells which send the electrical signals on to the brain where they are understood as sounds. However, there are important structural differences between the inner ear of vertebrates and invertebrates like the fruit fly. These differences have lead researchers to believe that transduction must work on different principles.
The research team compared real data – from measurements of the amount of cochlear amplification found in the fruit fly inner ear – to the output of their model and found that around 20 transducers per sensory cell are enough to describe the real data accurately. This is the same as the number of "hairs" on a hair cell. Their results both describe the hearing organ comprehensively and open up the field of deafness research to Drosophila genetics. By manipulating the genes which control the transducers, scientists can identify which molecules are involved in allowing hair cells to send signals to higher brain centres.
ENDS
Photograph and caption
Vivienne Michael, CEO of Deafness Research UK
About Deafness Research UK
• Deafness Research UK is the country’s only charity dedicated to finding new cures, treatments and technologies for deaf, hard of hearing and other hearing impaired people.
• The charity supports high quality medical research into the prevention, diagnosis and treatment of all forms of hearing impairment including tinnitus.
• The Deafness Research UK Information Service provides free information and advice based on the latest scientific evidence and informed by leading experts. The Information Service can be contacted on Freephone 0808 808 2222
• For more information on research into deafness, tinnitus and other hearing conditions, log on to the website at www.deafnessresearch.org.uk where you can access a wide range of information. Alternatively you can e-mail Deafness Research UK at info@deafnessresearch.org.uk
• One in seven people in the UK – almost nine million people - suffer hearing loss.
• Deafness Research UK was founded in 1985 by Lord (Jack) and Lady Ashley of Stoke.
• In January 2008, Action for Tinnitus Research (ATR) was linked with Deafness Research UK under a uniting direction order under section 96(6) of the Charities Act 1993.
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Ref: DRUK0091 – Dr Joerg Albert